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The Breast Cancer Vaccine Breakthrough: What Every Woman Should Know

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When it comes to cancer, triple-negative breast cancer (TNBC) is one of the deadliest. This is because it is difficult to manage with traditional treatments, unlike other breast cancers. Luckily, there is a potential breakthrough in preventing the menace. Anixa Biosciences, in collaboration with the Cleveland Clinic, has risen to the challenge by coming up with a vaccine that it hopes can stop the ailment. Here is some vital information you should know about the vaccine breakthrough.

The Company that Developed it and How Far Gone They are. 

Anixa Biosciences is a biotech firm that is championing the vaccine. The vaccine has been developed at the Cleveland Clinic, but it is licensed to Anixa. It works by targeting a protein known as alpha-lactalbumin, commonly found in breast cancer cells. However, in several cases of TNBC, the protein is the most affected.

The first phase started around 2021, with clinical dosing of all participants expected to end by 2025. The project has been funded by the US Department of Defense. Participants in the trials are from three main groups:

  • Women previously treated for TNBC
  • Women with High Genetic Risk
  • Women who have received immunotherapy

Expert Opinions About the Vaccine

Opinions abound in the medical field about the prospects of the vaccine, with many tilting towards a cautiously optimistic view. Dr. Thomas Budd, an investigator at the Cleveland Clinic, states that the vaccine offers a unique type of protection for women at high risk. He further emphasized that this type of preventive vaccine could be a lifesaver for millions of women.

Furthermore, a reputable oncologist, Dr. Rima Patel of Sinai Hospital, is happy with the approach used in developing the vaccine. She said that while many are focusing on treatment, they aim for prevention. She is hopeful that the vaccine, when fully completed, will help many women.

Meanwhile, Anixa CEO Dr. Amit Kumar opined that early results are promising and that the firm is committed to making the project a success.

Read Also : Science-Backed Tips for Better Sleep

Stages of Administration

The vaccine will go through a series of stages. The first phase trials will be used to monitor how the immune system responds to it and possible side effects. For phase two, it will be used in a neoadjuvant setting, where women with TNBC will be administered the vaccine alongside immunotherapy and chemotherapy. The second will be in a preventive setting for women who are predisposed to breast cancer with no formation of the cells yet.

Animal Trials and Safety Concerns

Before human trials are considered, the Anixa vaccine was tested on mice that are prone to having breast cancer. The results were encouraging, as these kids didn’t develop any tumors. As per safety concerns, participants in the first phase only showed minor side effects like soreness. There have not been any adverse reactions to the vaccine. These positive early safety signs show so much promise, with trials expected in larger groups soon.

Bottom Line 

By focusing on prevention rather than treatment, the vaccine breakthrough is a life-changing strategy worth appreciating. Early human trials are showing good signs both on safety and strong immune reactions. While there is still a long way to go, the signs are good.

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Exercise May Aid Stroke Recovery by Transporting Mitochondria to the Brain

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Photo: Getty Images

Exercise may support recovery after a stroke by facilitating the transfer of healthy mitochondria to damaged areas of the brain. Mitochondria are small structures inside cells that produce energy. After a stroke, many brain cells lose their energy supply. Exercise may help cellular energy production and improve neurological recovery.

Exercise Boosts the Release of Healthy Mitochondria

Exercise Drills: Istock

Regular exercise increases mitochondrial production. During physical activity, cells are stimulated to make more mitochondria. Some supporting cells can release healthy mitochondria into the surrounding environment. However, knowing the best time to workout is ideal for better results.

Research suggests that these mitochondria can move beyond their original cells. Exercise may increase this release, creating a greater availability of healthy mitochondria that the body can use to support damaged brain tissues.

Exercise Improves Blood Flow that Carries Mitochondria

Strength Exercise: IStock

Exercise increases blood circulation. With increased blood flow, oxygen, nutrients, and cellular components circulate easily. This improved circulation helps transport mitochondrial signals toward the brain.

After a stroke, blood flow to the affected brain is limited. By engaging in regular exercise, circulation improves. This may increase the likelihood that healthy mitochondria reach affected brain cells.

Exercise helps Brain Cells Receive Mitochondria

Exercise triggers the release of chemical signals that helps repair themselves. These signals may help brain cells take in healthy mitochondria from nearby cells. This process may support energy production inside damaged neurons.

Once inside the brain cells, healthy mitochondria can improve cellular energy production and reduce cellular repair. This may help neurons survive and regain function after stroke.

Read also : Fiber Supplements That Support Weight Management and Brain Health

Exercise Supports Mitochondrial Repair inside the Brain

Arms exercises: IStock

Physical activity also improves the health of mitochondria already present in brain cells. Exercise supports cellular repair systems that remove to clean damaged mitochondria and replace them with healthier ones.

This process supports better energy use and reduces damaging byproducts inside brain cells. Stronger mitochondrial function allows the brain to promote healing and rebuild lost connections after a stroke.

Exercise Strengthens Brain Recovery through Energy Support

Recovery after stroke depends on the brain’s ability to form new pathways. This process requires energy. With better mitochondrial delivery and function, exercise may provide the required energy for motor recovery.

Safe exercise programs are commonly used in stroke rehabilitation. Aside from strength and balance, these activities may help the brain recover more effectively.

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Fiber Supplements That Support Weight Management and Brain Health

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Fiber supplements are increasingly recognized for their potential to aid weight management and contribute to cognitive health. While not a replacement for a balanced diet or medical guidance, research indicates that specific fibers, particularly soluble and prebiotic types, can influence appetite, metabolism, and gut-brain communication.

Dietary fiber is a carbohydrate the body cannot fully digest. Soluble fibers, including psyllium, inulin, and beta-glucans, absorb water in the gut, slow digestion, and help create a sense of fullness. Insoluble fibers support regular bowel movements and overall digestive function. Introducing fiber supplements can help supplement dietary intake, particularly when daily fiber consumption is low.

Photo Credit – Google

Clinical studies show measurable effects on weight management. In a randomized trial, participants taking a multi-fiber supplement, containing glucomannan, psyllium, inulin, and apple fiber, experienced greater reductions in body weight, body mass index, and visceral fat than those taking a placebo. Improvements in inflammatory markers were also observed. Other trials demonstrated that supplementing 5–7 grams of fiber daily alongside a reduced-calorie diet enhanced weight loss compared with diet alone, likely due to increased satiety and slower gastric emptying.

Photo Credit – Google

Emerging research also links fiber intake to cognitive outcomes. Observational studies show that higher total fiber intake correlates with better performance on memory and processing-speed tests in older adults. Some trials with prebiotic fibers, such as inulin and fructo-oligosaccharides, found that participants over 60 experienced improvements in memory tests and gut microbiome composition after 12 weeks of supplementation. These findings suggest that fiber’s effects on inflammation, blood sugar stability, and gut bacteria may contribute to brain health, although more research is needed to establish causation.

Photo Credit – Google

Certain fiber supplements have the strongest evidence base. Psyllium husk is well-documented for weight management and cholesterol regulation. Glucomannan is valued for its high viscosity and appetite-regulating properties. Inulin and fructo-oligosaccharides act as prebiotics, supporting beneficial gut bacteria and the gut-brain axis. Beta-glucans from oats or barley contribute soluble fiber that promotes fullness and metabolic regulation.

Practical considerations are important. Effective doses in studies typically range from several grams per day, and benefits are most pronounced when supplements complement a balanced diet. Sudden increases in fiber can cause bloating or gas, so gradual introduction with adequate water is recommended. Fiber supplements support dietary strategies, but they are not standalone solutions for weight loss or cognitive enhancement.

Photo Credit – Google

In conclusion, fiber supplements, particularly soluble and prebiotic varieties, can enhance weight management efforts and support factors linked to cognitive function. They help regulate appetite, influence metabolic signals, and contribute to gut-brain interactions. While not a cure or replacement for healthy lifestyle practices, incorporating fiber supplements offers measurable benefits for metabolic and brain health.

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Does Creatine Work for Weight Loss?

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About Creatine 

Creatine is a natural element that is found in the body and in foods such as fish. It can be found in the muscles and gives the body energy during physical activities. However, in sports or when engaging in fitness activities take Creatine supplements.

How Creatine Works in the Body 

Creatine :Iherb

Creatine helps produce ATP, a molecule that is a huge source of energy. When your creatine levels diminish, it helps replenish them. This is one of the reasons why it is associated with strength gain and improved performance.

 

Read Also : 7 Vitamins that Supercharge your Body and Brain

Does Creatine Cause Weight Loss? 

Creatine : Wellness Blog

Using Creatine doesn’t lead to actual weight loss in the real sense. Also, it doesn’t increase fat burning nor reduce appetite. Some people even note the slight gain in weight after using it for some time. This is because there is water drawn into the muscles when used regularly.

How can Creatine support Weight Loss Indirectly? 

Creatine ‘ Ubuy

Although Creatine doesn’t burn fat, it can help support weight loss indirectly. Because it improves performance, taking Creatine can lead you to train harder. When your workouts increase, there will be an increase in the burning of calories. If this is sustained it can support fat loss, when combined with a good diet.

Why Should You Consider Using Creatine? 

Creatine : Amazon

Creatine is a good choice for those who indulge in workouts and high-intensity training. It also benefits those who want to maintain muscle and strength support for the long term. However, you shouldn’t substitute it for proper nutrition or regular physical activities.

Creatine isn’t a weight loss solution but it helps increase energy levels. While it can’t reduce body fat directly, it can make workout mode effective. When used in combination with a balanced diet and regular exercise, it leads to a healthier body.

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