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Lenacapavir: The $40 Breakthrough Drug Changing the Fight Against HIV

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Lenacapavir is being described as one of the most promising tools in the fight against HIV. Known by brand names such as Yeztugo (for prevention) and Sunlenca (for treatment), it belongs to a new class of HIV drugs called capsid inhibitors. Unlike current daily pills, lenacapavir is adminsited as an injection only twice a year. For South Africa, where HIV continues to affect millions, this development could be transformative.

Why Lenacapavir Matters

The HIV capsid is the protective shell around the virus. Lenacapavir works by blocking this shell’s ability to function properly at different stages of the virus’s life cycle. Because targets multiple stages of the virus’s life cycle, it remains effective against HIV strains resistant to other medicines.

Globally, lenacapavir has already been approved for people with multidrug-resistant HIV-1, but it has the potential to be better than pre-exposure prophylaxis (PrEP). In July 2025, the World Health Organization (WHO) recommended lenacapavir as a new HIV prevention option.

Clinical Results Show Positive Results 

Trials have shown extraordinary results. In one test, cisgender women who received lenacapavir had zero new HIV infections. In another trial, involving cisgender men, transgender, and gender-diverse participants, infection rates dropped by about 96% compared to background levels.

Across both trials, over 99.9 % of participants receiving lenacapavir stayed HIV negative. A large comparison also confirmed that the injection was more effective than the daily pill Truvada.

Read Also : Surprising Connection Between Viagra and Increasing Divorce Rate

South Africa’s HIV Challenge

About 7.8 million South Africans, roughly 12.7 % of the population live with HIV. Each year, more than 200,000 new infections are recorded, with young women and girls leading the way.

Daily PrEP pills come with challenges such as stigma, long clinic visits, and costs. A twice-yearly injection could remove these problems.

When Will It Arrive ?

The  government has signaled interest in rolling out lenacapavir at more than 300 public clinics between 2026 and 2028, especially in high-burden districts. Before that, it needs approval from SAHPRA (South African Health Products Regulatory Authority) and inclusion on the Essential Medicines List, which allows public procurement.

Funding is also a factor. The Global Fund has already budgeted around R513 million to help South Africa secure supplies, even before generics hit the market.

The $40 Breakthrough

In the United States, branded lenacapavir can cost up to USD 28,000 per year, which is expensive for many people. But in September 2025, a global deal was struck that will allow lenacapavir to be available for just USD 40 (about R730) per year across low and middle-income countries, starting in 2027.

This price is lower than what South Africa currently spends on daily PrEP pills, which cost about R629 per person annually . If the country is included in the deal, the cost barrier that has long slowed new HIV technologies could finally be overcome.

Challenges Ahead

Many are looking towards  SAHPRA and other policy bodies to give the greenlight for its use. Clinics will need to adapt by managing injections and tracking patients. Communities need to be educated about the injection and its benefits.

The Bottom Line

Lenacapavir offers a opportunity to reshape the global fight against HIV. With near-100% protection in trials and a plan to bring the price to $40 per year, this is a welcome development.

As HIV continues to affect millions of lives, lenacapavir could become the tool that turns the tide. The next few years are crucial as this breakthrough is expected to change millions of lives.

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Health

Why Women Over 35 Suddenly Feel Like Their Bodies Are Changing

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Photo: Pinterest

Many women reach their mid-thirties and suddenly feel like their bodies are working differently. Weight becomes harder to manage, energy levels drop faster, sleep patterns shift and recovery after long days takes more time than it used to. Even women who maintain the same eating habits and fitness routines often notice changes that seem to appear without warning. Health experts say this stage is more common than many women realise.

Hormonal Changes Start Earlier Than Many Women Realise

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One of the biggest drivers of these changes is hormone fluctuation. While menopause may still be years away, hormone levels can begin shifting much earlier than expected, affecting several systems in the body at once. Oestrogen and progesterone influence more than reproductive health; they also play a role in metabolism, sleep, appetite, mood, skin elasticity and fat storage. As these hormones fluctuate, many women begin experiencing bloating, lower energy levels, mood swings, brain fog, changes in menstrual cycles and weight gain around the stomach, often while continuing with the same lifestyle habits.

Weight Gain Becomes More Difficult to Manage

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Weight gain is one of the most common concerns women report after 35, and it is not always linked to diet alone. Muscle mass naturally decreases with age, especially when strength training is not part of a regular routine, and since muscle supports metabolism, the body may begin burning energy less efficiently over time. This shift, combined with hormonal changes, often makes weight easier to gain and harder to lose even when eating patterns remain unchanged.

Lifestyle Pressures and Stress Begin to Show

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Many women in their mid-thirties are managing multiple responsibilities at once, including careers, parenting, financial pressure and caregiving roles, and over time this builds chronic stress. Increased stress levels can raise cortisol, which is linked to disrupted sleep, fatigue, stronger cravings and fat distribution around the abdominal area. The result is often a body that feels less responsive, even without major changes in diet or activity.

Sleep Patterns Start to Shift

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Sleep also begins to feel different after 35, with many women reporting lighter rest or waking up more frequently during the night. Hormonal changes and ongoing stress both contribute to these disruptions, and poor sleep in turn affects appetite regulation, mood, concentration and metabolism. Over time, this creates a cycle where tiredness, cravings and low energy begin to reinforce each other.

Skin and Hair Changes Become More Noticeable

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Changes in skin and hair are also common during this stage of life as collagen production naturally slows with age, affecting skin firmness and elasticity. Alongside this, some women notice drier skin, thinning hair, changes in texture and more visible fine lines. These shifts are influenced not only by age but also by hydration, nutrition, stress levels and sleep quality, all of which play a role in how the skin and hair respond.

More Women Are Talking Openly About It

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In recent years, conversations around women’s health and ageing have become more open, with more women discussing perimenopause, hormonal changes, metabolism shifts and body image after 35. Social media and health platforms have helped normalise these discussions, making it easier for women to recognise that these experiences are shared rather than isolated or unusual.

The Focus Is Shifting Toward Long-Term Health

Health experts increasingly encourage women over 35 to focus less on appearance-based pressure and more on long-term wellbeing, including strength training, balanced nutrition, regular movement, stress management, better sleep habits and routine medical check-ups. Understanding these changes helps many women make sense of what is happening in their bodies and respond with adjustments that support long-term health rather than self-blame.

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Health

The 5 Best Anti-Inflammatory Drinks to Enjoy Throughout the Day

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Inflammation is the body’s natural way of protecting itself against illness. When treated poorly, it causes serious health complications. To control inflammation, certain drinks with antioxidants can be helpful. These drinks work best when combined with a healthy lifestyle.

Green Tea

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Green tea contains catechins which is a powerful antioxidant that relieves inflammation. Studies suggest people who drink green tea enjoy better metabolic function. Drinking two daily is ideal. You can also add lemon for better absorption.

Turmeric Tea

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Turmeric tea, also known as golden milk contains curcumin. This Curcumin reduces bloating in the body. Turmeric tea is used with warm milk and honey for additional benefits. It is recommended for those dealing with joint discomfort. This tea supports immunity and brain health.

Read Also: Fiber Supplements That Support Weight Management and Brain Health

Ginger Tea

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Ginger tea is used as a traditional medicine. It contains natural compounds called gingerols and shogaols. Fresh ginger tea is best drunk after meals to support gut health. Athletes take ginger tea for muscle strength. You should combine ginger with lemon for Best results.

Tart Cherry Juice

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Tart cherry juice is common among athletes due to its high anthocyanin content. Anthocyanins help reduce inflammation and muscle soreness. Studies suggest tart cherry juice supports sleep quality because of its melatonin content. Many people drink a small serving after workouts.

Kefir

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Kefir is a fermented milk drink rich in probiotics. Researchers link regular probiotic intake with low levels of inflammation. Unlike most yogurt drinks, kefir sugar is low. Kefir’s nutritional contents are protein and vitamin B12. You can blend it with berries for more antioxidant benefit.

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Health

Thobeka Mbane Opens Up With A Heartfelt Appeal, Revealing Details Of A Long-Standing Medical Journey

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Photo: Instagram

Thobeka Mbane has opened up on the health travails that affected both her life and work. Mbane narrated her experience of living with scoliosis linked to her childhood. She says it has influenced her view of fashion.

“As a creative person with a physical disability, I’ve experienced firsthand the challenges of navigating an industry that often prioritises able-bodiedness,” Thobeka says.

Mbane talks about the toll this condition had on her. She describes how each phase of her life has required adjustments, such as changes in daily routines, hospital visits, and work.

Photo: Instagram

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She uses her platform to call attention to accessibility barriers in the fashion industry. She has styled popular figures such as Zozibini Tunzi and Sho Madjozi. She also complained about limited opportunities for disabled creatives.

While there’s been progress in recent years, I believe there’s still much work to be done to create a truly inclusive and affirming environment for disabled creatives and audiences. I think it’s essential for the industry to prioritise accessibility, provide opportunities for disabled creatives to showcase their work, and engage in open and honest dialogue about ableism and its impact on our community.” She said

Photo: Instagram

By speaking honestly about the complexities of living with a long-term condition, issues that are avoided in the creative industry are discussed openly. Her story shows how people can be successful despite their personal struggles.

In sharing her experience, Mbane advocates for inclusion in the industry. Her advocacy focuses on improving accessibility for future creatives with disabilities.

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